
Unlike other systems in the body, such as circulatory, digestive, nervous, etc., the endocannabinoid system was not discovered until 1988, when scientists identified the first cannabinoid receptor in a rat. And in 1990, researchers at the National Academy of Medicine found that cannabinoid receptors are present throughout our bodies, with the highest concentrations located in our immune cells, central nervous system and organs.
Viewed within the scope of all scientific discoveries since humans first walked upright, the endocannabinoid system (ECS) is new. Despite its novelty, the endocannabinoid system is important, and it explains why CBD works. So, we provide a basic primer here.
The Endocannabinoid System: What We Know
We have learned a great deal about the ECS in the last 30 years:
The Endocannabinoid System: How It Works, or Locks and Keys
Put very simply, the ECS consists of endocannabinoids, cannabinoid receptors and enzymes, all working together to maintain homeostasis.
Think of the system this way...
• An endocannabinoid is a key,
• A cannabinoid receptor is a lock, and
• Enzymes are the hidden treasure stashed inside a locked box, working to break down excess endocannabinoids in order to keep the ECS system in balance.
The endocannabinoids — the keys — include...
• Anandamine or AEA. Some call this the “bliss” molecule because it activates the body’s internal reward feeling. Interestingly, some
research has shown that the happy rush you experience after a great exercise workout may be created by AEA, rather than endorphins.
• 2-arachidonoyl-glycerol, or 2-AG. This regulates immune and inflammation responses.
While there are likely more endocannabinoids, AEA and 2-AG are the endocannabinoids scientists understand the most.
The cannabinoid receptors — the locks — are...
• These receptors are found mostly in the central nervous system and GI system. Scientists believe CB1 receptors regulate appetite, sleep,
memory and chronic pain.
• Found mostly in the peripheral nervous system, these receptors regulate immune and inflammatory responses.
The Endocannabinoid System: Complicated Locks and Keys
The Endocannabinoid System:
Wrapping Things Up
The science of the ECS is constantly changing. We will work hard to keep this page updated, and we also intend to use our blog as a place we can comment on the science as it is revealed.
In summary: